Original articles are in-depth research reports intended to communicate new data and discoveries, pushing the boundaries of knowledge. Typically published in peer-reviewed journals, they can be nourished from a wide range of sources, from clinical trials to new laboratory findings. Complex scientific data should be presented in a clear, organised, yet engaging style in order to reach not only experts in the field but also those outside it. We will bridge that gap while adhering to the journal’s guidelines, helping gain acceptance and facilitating a well-informed decision.